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Index > Protein center > Cyp1b1(Gene name) > Mouse
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  • Cyp1b1 (Gene name),
  • Cytochrome P450 1B1 (Protein name ),  CP1B1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Cyp1b1(Cyp1-b1);
    Protein name:
    Cytochrome P450 1B1;
    Alternative:
    Cytochrome P450CMEF(Cytochrome P450EF);CYPIB1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
    Subcellular Location:
    Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    543
    Sequence:
    50:
    MATSLSADSP | QQLSSLSTQQ | TTLLLLFSVL | AAVHLGQWLL | RQWQRKPWSS | 
    100:
    PPGPFPWPLI | GNAAAVGQAS | HLYFARLARR | YGDVFQIRLG | SCPVVVLNGE | 
    150:
    SAIHQALVQQ | GSIFADRPPF | ASFRVVSGGR | SLAFGHYSEH | WKTQRRSAYS | 
    200:
    TMRAFSTRHP | RSRGLLEGHA | LAEARELVAV | LVRRCAGGAF | LDPTQPVIVA | 
    250:
    VANVMSAVCF | GCRYNHDDAE | FLELLSHNEE | FGRTVGAGSL | VDVLPWLQLF | 
    300:
    PNPVRTTFRK | FEQLNRNFSN | FVLDKFLRHR | ESLVPGAAPR | DMTDAFILSA | 
    350:
    EKKASGAPGD | DSSGLDLEDV | PATITDIFGA | SQDTLSTALL | WLLILFTRYP | 
    400:
    DVQARVQAEL | DQVVGRDRLP | CMSDQPNLPY | VMAFLYESMR | FSSFLPVTIP | 
    450:
    HATTANTFVL | GYYIPKNTVV | FVNQWSVNHD | PAKWPNPEDF | DPARFLDKDG | 
    500:
    FINKALASSV | MIFSVGKRRC | IGEELSKMLL | FLFISILAHQ | CNFKANQNES | 
    543:
    SNMSFSYGLT | IKPKSFRIHV | SLRESMELLD | NAVKKLQTEE | GCK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cytochrome P450 1B1
    Cat.:
    E10140r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Cytochrome P450 1B1
    Cat.:
    E10140h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Cytochrome P450 1B1
    Cat.:
    E10140m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytochrome P450 1B1
    Cat.:
    U10140m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytochrome P450 1B1
    Cat.:
    U10140h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytochrome P450 1B1
    Cat.:
    U10140r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Cytochrome P450 1B1
    Cat.:
    P10140Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Cytochrome P450 1B1
    Cat.:
    P10140Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Cytochrome P450 1B1
    Cat.:
    P10140Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Cytochrome P450 1B1
    Monoclonal Antibody for Mouse Cytochrome P450 1B1
    Monoclonal Antibody for Mouse Cytochrome P450 1B1
    Protein for Mouse Cytochrome P450 1B1
    Protein for Mouse Cytochrome P450 1B1
    Protein for Mouse Cytochrome P450 1B1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1."
      Shen Z. , Liu J. , Wells R.L. , Elkind M.M.
      DNA Cell Biol.13:763-769(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C3H.
    2. 2.
      "Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression."
      Savas U. , Bhattacharyya K.K. , Christou M. , Alexander D.L. , Jefcoate C.R.
      J. Biol. Chem.269:14905-14911(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C3H.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Bone.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Identification of a cytochrome P450 gene by reverse transcription-PCR using degenerate primers containing inosine."
      Shen Z. , Wells R.L. , Liu J. , Elkind M.M.
      Proc. Natl. Acad. Sci. U.S.A.90:11483-11487(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 361-466
    6. 6.
      "Regulation of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblast (C3H10T1/2) cells by protein kinase C (PKC)."
      Ikegwuonu F.I. , Christou M. , Jefcoate C.R.
      Biochem. Pharmacol.57:619-630(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    7. 7.
      "Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1."
      Choudhary D. , Jansson I. , Stoilov I. , Sarfarazi M. , Schenkman J.B.
      Drug Metab. Dispos.32:840-847(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
    8. 8.
      "CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression."
      Tang Y. , Scheef E.A. , Wang S. , Sorenson C.M. , Marcus C.B. , Jefcoate C.R. , Sheibani N.
      Blood113:744-754(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VASCULAR DEVELOPMENT AND ANGIOGENESIS
    9. 9.
      "CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress."
      Tang Y. , Scheef E.A. , Gurel Z. , Sorenson C.M. , Jefcoate C.R. , Sheibani N.
      Am. J. Physiol.298:C665-C678(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    11. 11.
      "Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells."
      Palenski T.L. , Sorenson C.M. , Jefcoate C.R. , Sheibani N.
      Lab. Invest.93:646-662(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VASCULAR HOMEOSTASIS;TISSUE SPECIFICITY;INDUCTION
    12. 12.
      "Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress."
      Zhao Y. , Wang S. , Sorenson C.M. , Teixeira L. , Dubielzig R.R. , Peters D.M. , Conway S.J. , Jefcoate C.R. , Sheibani N.
      Mol. Cell. Biol.33:4225-4240(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRABECULAR MESHWORK DEVELOPMENT;DISRUPTION PHENOTYPE
    13. 13.
      "Specificity determinants of CYP1B1 estradiol hydroxylation."
      Nishida C.R. , Everett S. , Ortiz de Montellano P.R.
      Mol. Pharmacol.84:451-458(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ESTROGEN METABOLISM
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